Work Title: A microfluidic platform to restore the angiogenic balance in preeclampsia

Communication Type: Poster

Event, Location:  Miniaturized Systems for Chemistry and Life Sciences (MicroTAS) 2018, Taiwan


Preeclampsia is a hypertensive disorder of pregnancy linked to placenta insufficiency. Preeclampsia is connected with maternal endothelial dysfunction due to the excess or the lack of angiogenic factors such as sFlt-1 (soluble Fms-like tyrosine kinase 1) and PlGF (placental growth factor) into the maternal circulation. Restoring the angiogenic balance is a solution to delay the birth of an extremely preterm infant. A microfluidic extra corporal technology was developed in this work which could be used as a platform to screen strategies to remove factors that play a causative role in the pathophysiology of preeclampsia.

By: Alexandre Lucile (Institut Curie, PSL Research University, CNRS, UMR 168, F-75005, Paris).